Implantable CMOS biomedical devices

J Ohta, T Tokuda, K Sasagawa, T Noda - Sensors, 2009 - mdpi.com
The results of recent research on our implantable CMOS biomedical devices are reviewed.
Topics include retinal prosthesis devices and deep-brain implantation devices for small …

Miniaturized optical neuroimaging in unrestrained animals

H Yu, J Senarathna, BM Tyler, NV Thakor, AP Pathak - NeuroImage, 2015 - Elsevier
The confluence of technological advances in optics, miniaturized electronic components and
the availability of ever increasing and affordable computational power have ushered in a …

A CMOS/thin-film fluorescence contact imaging microsystem for DNA analysis

RR Singh, D Ho, A Nilchi, G Gulak… - IEEE Transactions on …, 2010 - ieeexplore.ieee.org
A hybrid CMOS/thin-film microsystem for fluorescence contact imaging is presented. The
microsystem integrates a high-performance optical interference filter and a 128× 128 pixel …

Needle-type imager sensor with band-pass composite emission filter and parallel fiber-coupled laser excitation

E Rustami, K Sasagawa, K Sugie… - … on Circuits and …, 2020 - ieeexplore.ieee.org
This paper presents an implantable fluorescence system with a composite emission filter
and fiber-coupled laser excitation. The composite structure of the short-pass interference …

Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca2+ fluoroimaging

T Kobayashi, M Haruta, K Sasagawa, M Matsumata… - Scientific reports, 2016 - nature.com
To better understand the brain function based on neural activity, a minimally invasive
analysis technology in a freely moving animal is necessary. Such technology would provide …

Microscopy imaging

AM Fine - US Patent 9,075,225, 2015 - Google Patents
Among other things, an imaging device has a photosensitive array of pixels, and a surface
associated with the array is configured to receive a specimen with at least a part of the …

Microscopy imaging

AM Fine, PH Gregson - US Patent 9,041,790, 2015 - Google Patents
Among other things, an imaging device has a photosensitive array of pixels, and a surface
associated with the array is configured to receive a specimen with at least a part of the …

Sample processing improvements for quantitative microscopy

AM Fine, H Macaulay - US Patent 10,502,666, 2019 - Google Patents
Among other things, a diluted sample is generated based on mixing a small sample of blood
with a one or more diluents. A thin film of the diluted sample is formed on the surface of a …

Novel implantable imaging system for enabling simultaneous multiplanar and multipoint analysis for fluorescence potentiometry in the visual cortex

T Kobayashi, M Motoyama, H Masuda, Y Ohta… - Biosensors and …, 2012 - Elsevier
Techniques for fast, noninvasive measurement of neuronal excitability within a broad area
will be of major importance for analyzing and understanding neuronal networks and animal …

Integrated In Vivo Neural Imaging and Interface CMOS Devices: Design, Packaging, and Implementation

DC Ng, T Nakagawa, T Mizuno, T Tokuda… - IEEE Sensors …, 2008 - ieeexplore.ieee.org
We have developed two CMOS devices to demonstrate the use of CMOS technology for
neural imaging and interfacing with the aim of studying the functions of the brain at the …