Brain state transitions primarily impact the spontaneous rate of slow-firing neurons

B Dearnley, M Jones, M Dervinis, M Okun - Cell Reports, 2023 - cell.com
The spontaneous firing of neurons is modulated by brain state. Here, we examine how such
modulation impacts the overall distribution of firing rates in neuronal populations of …

Corn peptides alleviate nonalcoholic fatty liver fibrosis in mice by inhibiting NLRP3 inflammasome activation and regulating gut microbiota

J Dang, T Cai, Y Tuo, S Peng, J Wang… - Journal of Agricultural …, 2024 - ACS Publications
This study aimed to investigate the effects of corn gluten-derived soluble epoxide hydrolase
(sEH) inhibitory peptides on nonalcoholic fatty liver fibrosis induced by a high-fat diet and …

Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes

S Someck, A Levi, HE Sloin, L Spivak… - Communications …, 2023 - nature.com
Multiple biophysical mechanisms may generate non-negative extracellular waveforms
during action potentials, but the origin and prevalence of positive spikes and biphasic spikes …

PhysMAP-interpretable in vivo neuronal cell type identification using multi-modal analysis of electrophysiological data

EK Lee, A Gul, G Heller, A Lakunina, S Jaramillo… - BioRxiv, 2024 - biorxiv.org
Cells of different types perform diverse computations and coordinate their activity during
sensation, perception, and motor control. While electrophysiological approaches can …

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics

NA Koch, BW Corrigan, M Feyerabend, RA Gulli… - Cell Reports, 2025 - cell.com
Cortical neurons in brain slices display intrinsic spike frequency adaptation (I-SFA) to
constant current inputs, while extracellular recordings show extrinsic SFA (E-SFA) during …

[HTML][HTML] Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy

F Wendling, E Koksal-Ersoz, M Al-Harrach… - Clinical …, 2024 - Elsevier
Objective The aim is to gain insight into the pathophysiological mechanisms underlying
interictal epileptiform discharges observed in electroencephalographic (EEG) and stereo …

[HTML][HTML] DREDge: robust motion correction for high-density extracellular recordings across species

C Windolf, H Yu, AC Paulk, D Meszéna, W Muñoz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
High-density microelectrode arrays (MEAs) have opened new possibilities for systems
neuroscience in human and non-human animals, but brain tissue motion relative to the array …

Arid1b haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypes

AH Marshall, MA Hanson, DJ Boyle, D Nagarajan… - bioRxiv, 2024 - biorxiv.org
Arid1b is a high confidence risk gene for autism spectrum disorder that encodes a subunit of
a chromatin remodeling complex expressed in neuronal progenitors. Haploinsufficiency …