The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

Global rates of obesity continue to rise and are necessarily the consequence of a long-term
imbalance between energy intake and energy expenditure. This is the result of an …

The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive
signals from both extrinsic factors and intrinsic inhibitory checkpoints,. Targeted gene editing …

Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on
CD4+ T cells through insulin receptor (IR) and IGF-1 receptor (IGF-1R) signaling. Here, we …

Despite numerous therapies, cancer remains one of the leading causes of death worldwide
due to the lack of markers for early detection and response to treatment in many patients …

The molecular oxygen (O2) paradox was coined to describe its essential nature and toxicity.
The latter characteristic of O2 is associated with the formation of reactive oxygen species …

Immunometabolism aims to define the role of intermediary metabolism in immune cell
function, with bioenergetics and the mitochondria recently taking center stage. To date, the …

Promoting brown fat-like phenotype in white adipose tissue has been a promising strategy
for the treatment of obesity. Vitamin D3 (VD3) has been indicated to affect differentiation of …

The avianuncoupling protein (avUCP) is a member of the mitochondrial transporter
superfamily that uncouples proton entry in the mitochondrial matrix from ATP synthesis. The …