Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

Determining causal relationships between distinct chromatin features and gene expression,
and ultimately cell behavior, remains a major challenge. Recent developments in targetable …

Particular chromatin modifications are associated with different states of gene transcription,
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …

The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …

The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and
genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono …

Rearrangements of MLL (encoding lysine-specific methyltransferase 2A and officially known
as KMT2A; herein referred to as MLL to denote the gene associated with mixed-lineage …

Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly,
its dysregulation can contribute to the development of tumors. Epigenetic modifications, such …

Male fertility throughout life hinges on the successful production of motile sperm, a
developmental process that involves three coordinated transitions: mitosis, meiosis, and …

Nucleosomes wrap DNA and impede access for the machinery of transcription. The core
histones that constitute nucleosomes are subject to a diversity of posttranslational …