Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

The endothelial semipermeable monolayers ensure tissue homeostasis, are subjected to a
plethora of stimuli, and their function depends on cytoskeletal integrity and remodeling. The …

The endoplasmic reticulum associated degradation (ERAD) pathway regulates protein
quality control at the endoplasmic reticulum. ERAD of lumenal and membrane proteins …

Degrons are minimal protein features that are sufficient to target proteins for degradation. In
most cases, degrons allow recognition by components of the cytosolic ubiquitin proteasome …

Terminally misfolded or otherwise damaged proteins of the Endoplasmic Reticulum (ER) are
degraded by the proteasome in a process termed Endoplasmic Reticulum Associated …