Interactions between cells and their surroundings are important for proper function and
homeostasis in a multicellular organism. These interactions can either be established …

In addition to long-term regulation of angiogenesis, angiogenic growth factor signalling
through nitric oxide (NO) acutely controls blood flow and haemostasis. Inhibition of this …

Extracellular vesicles (EV) are membranous particles (30–1,000 nm in diameter) secreted by
cells. Important biological functions have been attributed to 2 subsets of EV, the exosomes …

The cellular microenvironment composition and changes therein play an extremely
important role in cancer development. Changes in the extracellular matrix (ECM), which …

Context.—Podoplanin is a mucin-type glycoprotein and a lymphatic endothelial marker.
Immunohistochemical staining for podoplanin is currently used as a routine pathologic …

Background: The identification of molecular and genetic markers to predict or monitor the
efficacy of bevacizumab (BV) represents a key issue in the treatment of metastatic colorectal …

Background Germline mutations in the FLCN gene are responsible for the development of
fibrofolliculomas, lung cysts and renal neoplasia in Birt-Hogg-Dube'(BHD) syndrome. The …

The classification of colorectal cancers (CRC) is currently based largely on histologically
determined tumour characteristics, such as differentiation status and tumour stage, ie, depth …

Angiogenesis is an important process for tumor growth and progression of various solid
tumors including urological cancers. Thrombospondins (TSPs), especially TSP-1, are …

Colorectal cancer is the second leading cause of cancer related death in the United States.
The majority of these deaths are due to metastasis, with the liver easily accounting as the …