For the treatment and prevention of ocular diseases, most patients are treated with
conventional drug delivery formulations such as eye drops or ointments. However, eye …

Magnetic resonance imaging of the eye and orbit (MReye) is a cross-domain research field,
combining (bio) physics,(bio) engineering, physiology, data sciences and ophthalmology. A …

The use of rodent models of glaucoma has been essential to understand the molecular
mechanisms that underlie the pathophysiology of this multifactorial neurodegenerative …

Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle
glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM) …

To investigate the characteristics of mutation myocilin proteins and glaucoma pathological
phenotype in transgenic mice with full-length human Pro370Leu mutant myocilin gene (Tg …

Trabecular meshwork dysfunction is the main cause of primary open angle glaucoma
(POAG) associated with elevated intraocular pressure (IOP). Mutant myocilin causes …

Accumulating evidence indicates that glaucoma is a multifactorial neurodegenerative
disease characterized by the loss of retinal ganglion cells (RGC), resulting in gradual and …

One of the most common diseases of old age in modern societies is glaucoma. It is strongly
connected with increased intraocular pressure (IOP) and could permanently damage vision …

Although elevated intraocular pressure (IOP) and age are major risk factors for glaucoma,
their effects on glaucoma pathogenesis remain unclear. This study examined the onset and …

Background Variant transthyretin-mediated amyloidosis (ATTR-v) is a well-characterized
disease affecting the neurologic and cardiovascular systems. Patisiran has been approved …