Prodrugs are designed to improve pharmaceutical properties of potent compounds and
represent a central approach in drug development. The success of the prodrug strategy …

Supramolecular living matter is remarkably complex in composition and structure and often
exists far from equilibrium. The biological manufacturing process involves …

Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …

Protein brushes not only play a key role in the functionality of neurofilaments but also have
wide applications in biomedical materials. Here, we investigate the effect of ionic strength on …

The self-assembly of micellar structures from diblock polymers that contain hydrophilic and
hydrophobic domains has been of great interest for the encapsulation of drugs and other …

Peptide‐drug conjugates (PDCs) are a type of self‐assembled prodrug with good potential
for drug delivery due to their excellent biocompatibility, high drug loading, and permanent …

Intrinsically disordered proteins (IDPs) play central roles in numerous cellular processes.
While IDP structure and function are often regulated by multisite phosphorylation, the …

Multimodal chromatography is a powerful tool which uses multiple modes of interaction,
such as charge and hydrophobicity, to purify protein-based therapeutics. In this work, we …

Surfactants, block copolymers, and other types of micellar systems are used in a wide variety
of biomedical and industrial processes. However, most commonly used surfactants are …

Abstract Poly (ethylene glycol)(PEG) is widely used in biotechnology-related applications yet
its temperature-dependent functionality is not well understood. Here, we use bovine serum …