Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

The mammalian host responds to infection with Borrelia spirochetes through a highly
orchestrated immune defense involving innate and adaptive effector functions aimed toward …

Phagocytosis and macropinocytosis are Ras-regulated and actin-driven processes that
depend on the dynamic rearrangements of the plasma membrane that protrudes and …

Lymphocyte migration is essential for the function of the adaptive immune system, and
regulation of T cell entry into tissues is an effective therapy in autoimmune diseases. Little is …

Filopodia are finger-like protrusions from the plasma membrane and are of fundamental
importance to cellular physiology, but the mechanisms governing their assembly are still in …

Ena/VASP proteins are powerful actin polymerases that drive the processive elongation of
actin filaments. Members of this protein family have been implicated in a variety of important …

Approximately 40% of patients with non-small cell lung cancer (NSCLC) develop bone
metastasis. The formin protein formin-like 1 (FMNL1) plays a key role in the pathogenic …

Simple Summary Borreliae are a group of highly motile bacteria that are characterized by
their corkscrew-like shape. They can be transferred by a tick bite to a human host and cause …

Background Lyme disease (LD) caused by Borrelia burgdorferi is the most prevalent tick-
borne disease. There is evidence that vaccines based on tick proteins that promote tick …

Borrelia burgdorferi is the causative agent of tick-borne Lyme disease. As a response to
environmental stress B. burgdorferi can change its morphology to a round body form. The …