The synthesis of spiro [furan-2, 1′-isoindolin]-3′-ones from 2-(4-hydroxybut-1-yn-1-yl)
benzonitriles and aryl aldehydes is demonstrated. It involves the initial formation of …

A metal-free Lewis acid-initiated protocol for the synthesis of highly substituted 3-
(dihydrofuran-3 (2 H)-ylidene) isobenzofuran-1 (3 H)-imines from 2-(4-hydroxybut-1-yn-1-yl) …

This review focuses on the carbocyclization reactions of alkyne-containing substrates
catalyzed by Brønsted acids. The electrophilic activation occurs either by direct protonation …

The nitrogen-interrupted Nazarov cyclization can be a powerful method for the
stereocontrolled synthesis of sp3-rich N-heterocycles. However, due to the incompatibility …

We report a Brønsted acid-catalyzed carbocyclization cascade, featuring condensation of an
alcohol/sulfonamide with an aldehyde followed by an intramolecular three-component …

The natural products having tetrahydropyran unit with multiple chiral centers serve as
magnificent building blocks for various active pharmaceutical ingredients (APIs).'Prins …

In this report, we describe an alkynyl halo-aza-Prins cyclization of 3-hydroxyisoindolones to
prepare aza-Prins products. These Prins adducts undergo oxidation at the 3-isoindolone …

This article is a comprehensive report describing our studies in the field of aza-alkynyl Prins
chemistry, comparing and contrasting the different reaction partners and reactivities …

A TMSOTf-mediated highly diastereoselective synthesis of isoxazolidine bearing three
contiguous stereocenters is described. This method utilizes O-propargyl hydroxylamines as …

A TfOH-promoted, metal-free protocol has been unveiled for the synthesis of spiro-furan
quinazolinones employing alkynol urea derivatives utilizing alkynyl Prins cyclization …