Background Emerging studies have investigated the association between puberty timing,
particularly age at menarche (AAM), and type 2 diabetes. However, whether this association …

During menopause, women's body composition, sex hormone profile, and metabolic profile
may change dramatically. In this review, we summarize studies examining whether the …

Objectives: Age at natural menopause (ANM) has become an important health issue in older
women. We explored secular trends in ANM in Korea during the past decade, and defined …

Some reproductive factors are found to be associated with metabolic outcomes in women;
however, little is known about reproductive lifespan characteristics and the mutual effect of …

Background: Reproductive and menstrual factors have been evaluated as surrogates for
long-term hormonal exposures in several prospective studies of colorectal cancer, yet …

Objectives: We aimed to conduct a systemic review and meta-analysis of the relevant
studies to further investigate the association between age at menarche and insulin …

The menarcheal age of Korean women has been rapidly decreasing for the last 50 years,
and the average menarcheal age of women born in the 1990s is approaching 12.6 years. In …

Background Declining age at menarche has been observed in many countries. In China, a
decrease of 4.5 months per decade in the average age at menarche among the majority …

STUDY QUESTION Is the age of onset of pubertal markers related to subsequent changes in
DNA methylation (DNAm)? SUMMARY ANSWER We identified 273 cytosine-phosphate …

自然绝经年龄与绝经后肥胖关系* Page 1 • 流行病学研究 • 自然绝经年龄与绝经后肥胖关系*
吴永君1,2,张维森1,周柏靖1,朱峰1,朱彤1,靳雅丽1,潘静1,江朝强1 [摘 要]目的 分析女性自然绝经 …