Plant cell responses to allelopathy: from oxidative stress to programmed cell death

K Šoln, M Klemenčič, JD Koce - Protoplasma, 2022 - Springer
Allelopathy is a plant–plant interaction in which one plant releases biologically active
compounds that have negative effects on the fitness of the target plant. The most …

Structural and functional diversity of caspase homologues in non-metazoan organisms

M Klemenčič, C Funk - Protoplasma, 2018 - Springer
Caspases, the proteases involved in initiation and execution of metazoan programmed cell
death, are only present in animals, while their structural homologues can be found in all …

The prodomain of Arabidopsis metacaspase 2 positively regulates immune signaling mediated by pattern‐recognition receptors

D Wu, H Tian, F Xu, J Yang, W Feng, S Bell… - New …, 2024 - Wiley Online Library
Metacaspases (MCs) are structural homologs of mammalian caspases found in plants, fungi,
and protozoa. Type‐I MCs carry an N‐terminal prodomain, the function of which is unclear …

Type III metacaspases: calcium‐dependent activity proposes new function for the p10 domain

M Klemenčič, C Funk - New Phytologist, 2018 - Wiley Online Library
Metacaspases are a subgroup of caspase homologues represented in bacteria, algae and
plants. Although type I and type II metacaspases are present in plants, recently discovered …

Yca1 metacaspase: diverse functions determine how yeast live and let die

DK Lam, G Sherlock - FEMS Yeast Research, 2023 - academic.oup.com
The Yca1 metacaspase was discovered due to its role in the regulation of apoptosis in
Saccharomyces cerevisiae. However, the mechanisms that drive apoptosis in yeast remain …

Evolution and structural diversity of metacaspases

M Klemenčič, C Funk - Journal of experimental botany, 2019 - academic.oup.com
Caspases are metazoan proteases, best known for their involvement in programmed cell
death in animals. In higher plants genetically controlled mechanisms leading to the selective …

Plant type I metacaspases are proteolytically active proteases despite their hydrophobic nature

KP van Midden, T Peric, M Klemenčič - FEBS letters, 2021 - Wiley Online Library
Plant metacaspases type I (MCA‐Is), the closest structural homologs of caspases, are key
proteases in stress‐induced regulated cell death processes in plants. However, no plant …

Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium

L Conchou, B Doumèche, F Galisson, S Violot… - Communications …, 2022 - nature.com
Metacaspases are caspase-like homologs which undergo a complex maturation process
involving multiple intra-chain cleavages resulting in a composite enzyme made of a p10 and …

The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system

A Shrestha, S Brunette, WL Stanford, LA Megeney - Cell Discovery, 2019 - nature.com
Metacaspase enzymes are critical regulatory factors that paradoxically engage apoptosis
and also maintain cell viability. For example, the Saccharomyces cerevisiae metacaspase …

Activity-based probes trap early active intermediates during metacaspase activation

V Štrancar, KP van Midden, D Krahn, K Morimoto… - Iscience, 2022 - cell.com
Metacaspases are essential cysteine proteases present in plants, fungi, and protists that are
regulated by calcium binding and proteolytic maturation through mechanisms not yet …