Warm autoimmune hemolytic anemia (wAIHA) is caused by increased erythrocyte
destruction by immunoglobulin G (IgG) autoantibodies, with or without complement …

Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …

Background In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-
of-function (GOF) mutations were first described to cause a novel multisystem disease of …

Evans' syndrome (ES) is defined as the concomitant or sequential association of warm auto-
immune haemolytic anaemia (AIHA) with immune thrombocytopenia (ITP), and less …

IKZF1/IKAROS is a key transcription factor of lymphocyte development expressed
throughout hematopoiesis. Heterozygous germline IKZF1 haploinsufficient (IKZF1 HI) and …

Autoimmune hemolytic anemia (AIHA) is a greatly heterogeneous disease due to
autoantibodies directed against erythrocytes, with or without complement activation. The …

Primary immunodeficiencies (PIDs), a heterogenous group of inborn errors of immunity, are
predetermined at birth but may evolve with age, leading to a variable clinical and laboratory …

Inborn errors of immunity are genetic disorders with broad clinical manifestations, ranging
from increased susceptibility to infections to significant immune dysregulation, often leading …

Cytotoxic T lymphocyte antigen 4 (CTLA-4) haploinsufficiency (CHAI) and
lipopolysaccharide-responsive beige-like anchor (LRBA) deficiency (LATAIE) are newly …