The congenital myasthenic syndromes (CMS) are a diverse group of genetic disorders
caused by abnormal signal transmission at the motor endplate, a special synaptic contact …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

A polymer chain of N atoms enjoys 3N-6 internal degrees of freedom, which gives rise to
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths …

Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the
mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ-and π …

Fast synaptic communication requires receptors that respond to the presence of
neurotransmitter by opening an ion channel across the post-synaptic membrane. The …

The Monod-Wyman-Changeux (MWC) model was conceived in 1965 to account for the
signal transduction and cooperative properties of bacterial regulatory enzymes and …

The nicotinic acetylcholine receptor (nAChR) belongs to a superfamily of pentameric ligand-
gated ion channels involved in many physiologic and pathologic processes. Among …

Ligand-gated ion channels mediate signal transduction at chemical synapses and transition
between resting, open, and desensitized states in response to neurotransmitter binding …