Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is
facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N …

Heritable changes to the transcriptome that are independent to changes in the genome are
defined as epigenetics. DNA methylation and posttranslational modifications of histones …

There has been an intense focus to uncover the molecular mechanisms by which fasting
triggers the adaptive cellular responses in the major organs of the body. Here, we show that …

This review covers briefly the major conditions, genetic and non‐genetic, sometimes leading
to abnormally elevated methionine, with emphasis on recent developments. A major aim is …

Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM)
synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding …

Protein methylation pathways comprise methionine adenosyltransferase (MAT), which
produces S-adenosylmethionine (SAM) and SAM-dependent substrate-specific …

MicroRNAs (miRNAs) and methionine adenosyltransferase 1A (MAT1A) are dysregulated in
hepatocellular carcinoma (HCC), and reduced MAT1A expression correlates with worse …