The basics and underlying mechanisms of mucoadhesion

JD Smart - Advanced drug delivery reviews, 2005 - Elsevier
Mucoadhesion is where two surfaces, one of which is a mucous membrane, adhere to each
other. This has been of interest in the pharmaceutical sciences in order to enhance localised …

Strategies to prolong the intravaginal residence time of drug delivery systems

E Baloglu, A Bernkop-Schnürch… - … of Pharmacy & …, 2009 - journals.library.ualberta.ca
The vagina has been studied as a favorable site for local and systemic delivery of drugs for
female-related conditions. There are a large number of vaginal medications on the market …

Mucoadhesive drug delivery systems

A Ahuja, RK Khar, J Ali - Drug Development and industrial …, 1997 - Taylor & Francis
Mucoadhesion in drug delivery systems has recently gained interest among pharmaceutical
scientists as a means of promoting dosage form residence time as well as improving …

A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration

F Madsen, K Eberth, JD Smart - Journal of controlled release, 1998 - Elsevier
The ability of mucoadhesive polymers to produce a large increase in the resistance to
deformation when incorporated into a mucus gel, relative to when the mucus gel and test …

An investigation into the role of water movement and mucus gel dehydration in mucoadhesion

SA Mortazavi, JD Smart - Journal of Controlled Release, 1993 - Elsevier
Water transfer between mucoadhesive formulations and mucus gels was investigated. The
water up-take by compacts and gels, measured in terms of weight gain, was evaluated at …

An investigation into the rheological, dielectric and mucoadhesive properties of poly (acrylic acid) gel systems

S Tamburic, DQM Craig - Journal of Controlled Release, 1995 - Elsevier
A range of recently introduced poly (acrylic acid) polymers (Carbopols 974P, 934P and EX-
214, Noveon AA-1) have been prepared as 2.5% w/w gels in water using three different …

Thermosensitive hydrogels for nasal drug delivery: the formulation and characterisation of systems based on N-trimethyl chitosan chloride

H Nazar, DG Fatouros, SM Van Der Merwe… - European Journal of …, 2011 - Elsevier
Towards the development of a thermosensitive drug-delivery vehicle for nasal delivery, a
systematic series of N-trimethyl chitosan chloride polymers, synthesised from chitosans of …

A comparison of different in vitro methods for measuring mucoadhesive performance

S Tamburic, DQM Craig - European Journal of Pharmaceutics and …, 1997 - Elsevier
The purpose of this study was to assess and compare several in vitro methods for measuring
mucoadhesive performance, using a controlled-stress rheometer and a penetrometer …

A rheological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel

F Madsen, K Eberth, JD Smart - Biomaterials, 1998 - Elsevier
The ability of mucoadhesive materials to produce a large increase in the resistance to
deformation when incorporated into a mucus gel, relative to when the mucus gel and test …

Factors influencing gel‐strengthening at the mucoadhesive‐mucus interface

SA Mortazavi, JD Smart - Journal of pharmacy and …, 1994 - Wiley Online Library
Mechanical spectroscopy was used to examine some of the factors that may affect mucus
gel strengthening: the effect of adding various concentrations of sodium chloride; …