Malaria is a major cause of childhood death throughout much of the tropical world. As a
result, it has exerted a powerful force for the evolutionary selection of genes that confer a …

Although the α+ thalassemias almost certainly confer protection against death from malaria,
this has not been formally documented. We have conducted a study involving 655 case …

Background The α-thalassaemias are the commonest genetic disorders of humans. It is
generally believed that this high frequency reflects selection through a survival advantage …

Objective: Anemia is a major public health concern in preschool children and pregnant
women in the developing world. While many studies have examined these two at-risk …

Background α-thalassemia results from decreased production of α-globin chains that make
up part of hemoglobin tetramers (Hb; α2β2) and affects up to 50% of individuals in some …

Objective: To determine accurately the relative frequencies and enzyme activities of the
polymorphic variants of G6PD in a homogeneous population in Nigeria. Setting: Abanla …

Objective In patients with sickle cell disease (SCD), the spleen commonly enlarges during
early childhood, but undergoes reduction in size and fibrosis from repeated episodes of …

The prevalence of human red blood cell (RBC) polymorphisms is high in areas of intense
Plasmodium falciparum transmission, and individuals carrying these genetic traits are …

Background Extensive studies investigating the role of host genetic factors during malaria
associate glucose-6-phosphate dehydrogenase deficiency with relative protection. G6PD …

Methods Red cell indices, blood film, sickle solubility test, Hb electrophoresis using alkaline
cellulose acetate membrane, and chromatographic patterns using Bio Rad HPLC Variant II …