Genomics of circadian rhythms in health and disease

F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Circadian rhythms and the molecular clock in cardiovascular biology and disease

S Crnko, BC Du Pré, JPG Sluijter… - Nature Reviews …, 2019 - nature.com
The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

Impact of circadian disruption on cardiovascular function and disease

SL Chellappa, N Vujovic, JS Williams… - Trends in Endocrinology …, 2019 - cell.com
The circadian system, that is ubiquitous across species, generates∼ 24 h rhythms in
virtually all biological processes, and allows them to anticipate and adapt to the 24 h …

Circadian time signatures of fitness and disease

J Bass, MA Lazar - Science, 2016 - science.org
Biological clocks are autonomous anticipatory oscillators that play a critical role in the
organization and information processing from genome to whole organisms. Transformative …

Circadian misalignment increases cardiovascular disease risk factors in humans

CJ Morris, TE Purvis, K Hu… - Proceedings of the …, 2016 - National Acad Sciences
Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This
increased risk cannot be fully explained by classic risk factors. One of the key features of …

Circadian clock-mediated regulation of blood pressure

LG Douma, ML Gumz - Free radical biology and medicine, 2018 - Elsevier
Most bodily functions vary over the course of a 24 h day. Circadian rhythms in body
temperature, sleep-wake cycles, metabolism, and blood pressure (BP) are just a few …

Circadian rhythm, clock genes, and hypertension: recent advances in hypertension

HM Costello, ML Gumz - Hypertension, 2021 - Am Heart Assoc
Accumulating evidence suggests that the molecular circadian clock is crucial in blood
pressure (BP) control. Circadian rhythms are controlled by the central clock, which resides in …

Circadian clock proteins and immunity

AM Curtis, MM Bellet, P Sassone-Corsi, LAJ O'Neill - Immunity, 2014 - cell.com
Immune parameters change with time of day and disruption of circadian rhythms has been
linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow …

Circadian integration of metabolism and energetics

J Bass, JS Takahashi - Science, 2010 - science.org
Circadian clocks align behavioral and biochemical processes with the day/night cycle.
Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms …

Circadian topology of metabolism

J Bass - Nature, 2012 - nature.com
Biological clocks are genetically encoded oscillators that allow organisms to anticipate
changes in the light–dark environment that are tied to the rotation of Earth. Clocks enhance …