[HTML][HTML] Insights about clinically approved and Preclinically investigated marine natural products

MA Ghareeb, MA Tammam, A El-Demerdash… - Current Research in …, 2020 - Elsevier
Since the early research efforts focusing on bioactive marine substances such as
spongouridine, from the marine sponge Cryptotethya crypta, marine natural products …

Antimicrobial compounds from microorganisms

C Amaning Danquah, PAB Minkah, I Osei Duah Junior… - Antibiotics, 2022 - mdpi.com
Antimicrobial resistance is an exigent public health concern owing to the emergence of
novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance …

Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors

A El-Demerdash, AA Al-Karmalawy, TM Abdel-Aziz… - RSC …, 2021 - pubs.rsc.org
Since its first report in December 2019, the novel coronavirus virus, SARS-CoV-2, has
caused an unprecedented global health crisis and economic loss imposing a tremendous …

Comprehensive virtual screening of the antiviral potentialities of marine polycyclic guanidine alkaloids against SARS-CoV-2 (COVID-19)

A El-Demerdash, AM Metwaly, A Hassan… - Biomolecules, 2021 - mdpi.com
The huge global expansion of the COVID-19 pandemic caused by the novel SARS-corona
virus-2 is an extraordinary public health emergency. The unavailability of specific treatment …

Investigating the hepatoprotective potentiality of marine-derived steroids as promising inhibitors of liver fibrosis

MA Tammam, F Pereira, O Aly, M Sebak, YM Diab… - RSC …, 2023 - pubs.rsc.org
It has been reported that organic extracts derived from soft corals belonging to the genus
Sarcophyton have exhibited a wide range of therapeutic characteristics. Based on …

Natural cholinesterase inhibitors from marine organisms

LWK Moodie, K Sepčić, T Turk, R Frangež… - Natural product …, 2019 - pubs.rsc.org
Covering: Published between 1974 up to 2018 Inhibition of cholinesterases is a common
approach for the management of several disease states. Most notably, cholinesterase …

Pharmacokinetics of marine-derived drugs

AN Shikov, EV Flisyuk, ED Obluchinskaya… - Marine drugs, 2020 - mdpi.com
Marine organisms represent an excellent source of innovative compounds that have the
potential for the development of new drugs. The pharmacokinetics of marine drugs has …

Marine macrolides with antibacterial and/or antifungal activity

TM Karpiński - Marine drugs, 2019 - mdpi.com
Currently, the increasing resistance of microorganisms to antibiotics is a serious problem.
Marine organisms are the source of thousands of substances, which also have antibacterial …

Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; …

AMS Mayer, ML Pierce, K Howe, AD Rodríguez… - Pharmacological …, 2022 - Elsevier
The 2018 marine pharmacology literature review represents a continuation of the previous
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …

[HTML][HTML] Pederins, mycalamides, onnamides and theopederins: Distinctive polyketide families with intriguing therapeutic potentialities

MA Tammam, A El-Demerdash - Current Research in Biotechnology, 2023 - Elsevier
In this comprehensive review article, an in-depth exploration over the period from 1949 to
2023 is presented, focusing on the discovery, chemistry, biosynthesis and therapeutic …