CD40/CD40L signaling as a promising therapeutic target for the treatment of renal disease
S Zhang, JD Breidenbach, BH Russell… - Journal of Clinical …, 2020 - mdpi.com
The cluster of differentiation 40 (CD40) is activated by the CD40 ligand (CD40L) in a variety
of diverse cells types and regulates important processes associated with kidney disease …
of diverse cells types and regulates important processes associated with kidney disease …
Potential diagnostic and prognostic of efferocytosis-related unwanted soluble receptors/ligands as new non-invasive biomarkers in disorders: a review
Efferocytosis is the process by which apoptotic cells are removed without inflammation to
maintain tissue homeostasis, prevent unwanted inflammatory responses, and inhibit …
maintain tissue homeostasis, prevent unwanted inflammatory responses, and inhibit …
Anti-CD40 antibody KPL-404 inhibits T cell-mediated activation of B cells from healthy donors and autoimmune patients
J Marken, S Muralidharan, NV Giltiay - Arthritis research & therapy, 2021 - Springer
Abstract Background CD40-CD40L is a key co-stimulatory pathway for B cell activation. As
such, its blockade can inhibit pathogenic B cell responses in autoimmune diseases, such as …
such, its blockade can inhibit pathogenic B cell responses in autoimmune diseases, such as …
Potential role of soluble CD40 receptor in chronic inflammatory diseases
AH Wagner, A Klersy, CS Sultan, M Hecker - Biochemical Pharmacology, 2023 - Elsevier
The CD40 receptor and its ligand CD154 are widely expressed in various immune-
competent cells. Interaction of CD154 with CD40 is essential for B-cell growth …
competent cells. Interaction of CD154 with CD40 is essential for B-cell growth …
3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation
B Yang, S Hou, J Zhao, Y Li - Bioengineered, 2022 - Taylor & Francis
The implications of the CD40-CD40 ligand (CD40L) signaling pathway in systemic lupus
erythematosus (SLE) were well documented, due to its important role among immune cells …
erythematosus (SLE) were well documented, due to its important role among immune cells …
Genetic variability of molecules involved in the disease pathogenesis in Leishmania infection
KYS Luquez, O Zerpa, CA Paz-Villarraga… - Experimental …, 2020 - Elsevier
Macrophages are the primary host cell for Leishmania parasites, by Toll like receptors (TLR-
MyD88) that are central components of the innate and adaptive immunity against leishmania …
MyD88) that are central components of the innate and adaptive immunity against leishmania …
Association of CD40 Gene Polymorphisms With Systemic Lupus Erythematosus and Rheumatoid Arthritis in a Chinese Han Population
Q Huang, WD Xu, LC Su, XY Liu, AF Huang - Frontiers in Immunology, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune
diseases. CD40 participates in inflammatory response, and promotes fibroblast proliferation …
diseases. CD40 participates in inflammatory response, and promotes fibroblast proliferation …
Screening and identification of key biomarkers in diabetic kidney disease and its complications: Evidence from bioinformatics and next generation sequencing data …
B Vastrad, C Vastrad - bioRxiv, 2023 - biorxiv.org
Diabetic patients are prone to diabetic kidney disease (DKD), which may cause
cardiovascular damage, hypertension and obesity, and reduce quality of life. As a result, the …
cardiovascular damage, hypertension and obesity, and reduce quality of life. As a result, the …
Two sides of the same medal: Noncoding mutations reveal new pathological mechanisms and insights into the regulation of gene expression
AS Wachs, J Bohne - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
Noncoding sequences constitute the major part of the human genome and also of pre‐
mRNAs. Single nucleotide variants in these regions are often overlooked, but may be …
mRNAs. Single nucleotide variants in these regions are often overlooked, but may be …
Disruption of Cd40 Attenuates Renal Injury and Improves Renal Function Following Experimental Renal Ischemia
S Zhang - 2020 - search.proquest.com
Chronic kidney disease is the progressive loss of kidney function, which is prevalent in up to
13% of the global population and has become a major health burden. As the loss of function …
13% of the global population and has become a major health burden. As the loss of function …