In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur
in different brain regions. These changes correlate with a range of clinical features, both …

The limbic system describes a complex of brain structures central for memory, learning, as
well as goal directed and emotional behavior. In addition to pathological studies, recent …

Abstract The endosome-associated GTPase Rab5 is a central player in the molecular
mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long …

Advances in computational neuroimaging techniques have expanded the armamentarium of
imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in …

Background Functional connectivity (FC) has shown promising results in assessing the
pathophysiology and identifying early biomarkers of neurodegenerative disorders, such as …

Mild cognitive impairment with the core clinical features of dementia with Lewy bodies is
recognized as a prodromal stage of dementia with Lewy bodies. Although grey matter …

The basal nucleus of Meynert (NBM) subserves critically important functions in attention,
arousal and cognition via its profound modulation of neocortical activity and is emerging as …

Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has
shown potential for the treatment of mild-to-moderate Alzheimer's disease (AD). However …

The basal forebrain cholinergic neurons provide acetylcholine to the cortex via large
projections. Recent molecular imaging work in humans indicates that the cortical cholinergic …

We reviewed studies that used diffusion tensor imaging (DTI) and tractography to
characterise white matter changes in Dementia with Lewy Bodies (DLB) and Parkinson's …