The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological
processes: oxygen transport and storage, electron transfer, drug and steroid metabolism …

The protective role of resveratrol in myocardial ischemia/reperfusion is not well understood.
The aim of this study was to investigate whether resveratrol modulates inflammation and …

Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and
obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro-and …

Disruption of the blood–brain barrier (BBB) and cerebral edema are the major pathogenic
mechanisms leading to neurological dysfunction and death after ischemic stroke. The brain …

The functional neural circuits are partially repaired after an ischemic stroke in the central
nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial …

Intestinal barrier plays key roles in maintaining intestinal homeostasis. Inflammation and
oxidative damage can severely destroy the intestinal integrity of mammals. Chlorogenic acid …

The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection
via activating the nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway and regulating …

Stroke is a complex disease involved oxidative stress-related pathways in its pathogenesis.
The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has …

Chrysin, apigenin, and luteolin are flavones that differ in their number of hydroxyl groups in
the B ring. In this study, we investigated the protection by chrysin, apigenin, and luteolin …