Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …

Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging …

This review on the role of neurofilaments as surrogate markers for axonal degeneration in
neurological diseases provides a brief background to protein synthesis, assembly, function …

Two immunocytochemical probes were used to specifically identify and localize heparan
sulphate proteoglycans (HSPGs) in 17 cases of Alzheimer's disease (AD). A monoclonal …

Various cytoskeletal proteins have been implicated in the cellular pathology of Alzheimer's
disease. A monoclonal antibody (SMI32) that recognizes nonphosphorylated epitopes on …

Detailed analyses of the neuropathologic changes in the cerebral cortex of elderly
individuals and Alzheimer's disease patients have demonstrated that certain components of …

In this study we investigated the primary and secondary visual areas of normal and
Alzheimer's disease brains by using the SMI32 antibody. It is known that in Alzheimer's …

Choline acetyltransferase immunohistochemistry showed that the human rostra1 brainstem
contained cholinergic neurons in the oculomotor, trochlear, and parabigeminal nuclei as …

Abstract Alzheimer's disease (AD), a classic neurodegenerative disorder, is characterized by
extensive yet selective neuron death in the neocortex and hippocampus that leads to …

Cue-directed shifts of spatial attention were examined for a letter-discrimination task in 15
patients with mild to moderate dementia of the Alzheimer type (DAT) and 15 healthy, age …