[HTML][HTML] Pregnancy-associated changes in pharmacokinetics: a systematic review

G Pariente, T Leibson, A Carls, T Adams-Webber… - PLoS …, 2016 - journals.plos.org
Background Women are commonly prescribed a variety of medications during pregnancy.
As most organ systems are affected by the substantial anatomical and physiological …

[HTML][HTML] Malaria: what's new in the management of malaria?

K Plewes, SJ Leopold, HWF Kingston… - Infectious Disease …, 2019 - id.theclinics.com
Malaria affected an estimated 216 million people causing 445,000 deaths in 2016. 1 This
reduced burden of disease and death is a result of more than a century of worldwide effort …

[HTML][HTML] Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax …

AP Phyo, P Jittamala, FH Nosten… - The Lancet Infectious …, 2016 - thelancet.com
Background Artefenomel (OZ439) is a novel synthetic trioxolane with improved
pharmacokinetic properties compared with other antimalarial drugs with the artemisinin …

[HTML][HTML] Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

S Bopp, P Magistrado, W Wong, SF Schaffner… - Nature …, 2018 - nature.com
Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria
elimination and threatens to spread to other malaria endemic areas. Understanding …

[HTML][HTML] Malaria in pregnancy

EN Takem, U D'Alessandro - Mediterranean journal of hematology …, 2013 - ncbi.nlm.nih.gov
Pregnant women have a higher risk of malaria compared to non-pregnant women. This
review provides an update on knowledge acquired since 2000 on P. falciparum and P. vivax …

Prevalence of metabolic syndrome among an urban population in Kenya

LU Kaduka, Y Kombe, E Kenya, E Kuria, JK Bore… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE Developing countries are undergoing an epidemiologic transition accompanied
by increasing burden of cardiovascular disease (CVD) linked to urbanization and lifestyle …

[HTML][HTML] Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis

LC Okell, M Cairns, JT Griffin, NM Ferguson… - Nature …, 2014 - nature.com
There are currently several recommended drug regimens for uncomplicated falciparum
malaria in Africa. Each has different properties that determine its impact on disease burden …

Malaria: an update on current chemotherapy

BJ Visser, M van Vugt, MP Grobusch - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Chemotherapy of malaria has become a rapidly changing field. Less than two
decades ago, treatment regimens were increasingly bound to fail due to emerging drug …

Structure-switching aptamer sensors for the specific detection of piperaquine and mefloquine

ES Coonahan, KA Yang, S Pecic, M De Vos… - Science Translational …, 2021 - science.org
Tracking antimalarial drug use and efficacy is essential for monitoring the current spread of
antimalarial drug resistance. However, available methods for determining tablet quality and …

Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria

GM Keating - Drugs, 2012 - Springer
Artemisinin-based combination regimens are recommended by WHO for the treatment of
uncomplicated Plasmodium falciparum malaria. One such combination comprises the …