Age-related macular degeneration (AMD) is a multifactorial disease associated with
anatomical changes in the inner retina. Despite tremendous advances in clinical care, there …

Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis
chinensis and other Berberis plants. BBR possesses various bioactivities, including …

Age-related macular degeneration (AMD) is the leading cause of visual impairments and
blindness worldwide in the elderly and its incidence strongly increases with ages. The …

Phloretin (PHL) is a dihydrochalcone flavonoid isolated from the peel and root bark of
apples, strawberries, and other plants with antioxidative characteristic. In this study, we …

Oxidative stress and diminished autophagy in the retinal pigment epithelium (RPE) play
crucial roles in the pathogenesis of age‐related macular degeneration (AMD). Enhancing …

Local deliver medication in a non-invasive pattern and attaining a long-term sustained
release at ocular regions to minimize side effects is fascinating for treatment and precision …

Although accumulated evidence supports the notion that calpain contributes to eye disease,
the mechanisms by which calpain promotes RPE injury are not defined. The present study is …

Isoquinoline alkaloids are an important class of natural products that are abundant in the
plant kingdom and exhibit a wide range of structural diversity and biological activities. With …

Defective autophagy in the retinal pigment epithelium (RPE) is involved in retinal
degeneration, mostly in the course of age-related macular degeneration (AMD), which is an …

Dry age-related macular degeneration (AMD) is a prevalent clinical condition that leads to
permanent damage to central vision and poses a significant threat to patients' visual health …