FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase
signaling pathway that has a fundamental role in many biologic processes including …

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non–small cell
lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes …

Introduction Proinflammatory cytokine interleukin-17A (IL-17A) is overexpressed in a subset
of patients with lung cancer. We hypothesized that IL-17A promotes a protumorigenic …

The success of targeted or immune therapies is often hampered by the emergence of
resistance and/or clinical benefit in only a subset of patients. We hypothesized that …

Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to
assess putative driver mutations identified by large-scale sequencing of human cancer …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …

Since its discovery 40 years ago, fibroblast growth factor (FGF) receptor (FGFR) signalling
has been found to regulate fundamental cellular behaviours in a wide range of cell types …

Despite improvement in our understanding of long noncoding RNAs (lncRNAs) role in
cancer, efforts to find clinically relevant cancer-associated lncRNAs are still lacking. Here …

The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells
and animals. However, model generation for drug development is still expensive and time …