Targeting Cyclin-Dependent Kinases: From Pocket Specificity to Drug Selectivity
Y Huang, W Liu, C Zhao, X Shi, Q Zhao, J Jia… - European Journal of …, 2024 - Elsevier
The development of selective modulators of cyclin-dependent kinases (CDKs), a kinase
family with numerous members and functional variations, is a significant preclinical …
family with numerous members and functional variations, is a significant preclinical …
Structural mass spectrometry probes the inhibitor-induced allosteric activation of cdk12/cdk13-cyclin k dissociation
Y Bai, Z Liu, Y Li, H Zhao, C Lai, S Zhao… - Journal of the …, 2023 - ACS Publications
The rational design and development of effective inhibitors for cyclin-dependent kinases 12
and 13 (CDK12 and CDK13) are largely dependent on the understanding of the dynamic …
and 13 (CDK12 and CDK13) are largely dependent on the understanding of the dynamic …
[HTML][HTML] Identification of a novel potent CDK inhibitor degrading cyclinK with a superb activity to reverse trastuzumab-resistance in HER2-positive breast cancer in vivo
RR Kuchukulla, I Hwang, SH Kim, Y Kye, N Park… - European Journal of …, 2024 - Elsevier
CDK12 is overexpressed in HER2-positive breast cancers and promotes tumorigenesis and
trastuzumab resistance. Thus CDK12 is a good therapeutic target for the HER2-positive …
trastuzumab resistance. Thus CDK12 is a good therapeutic target for the HER2-positive …
Research progress of anticancer drugs targeting CDK12
Z Yan, Y Du, H Zhang, Y Zheng, H Lv… - RSC Medicinal …, 2023 - pubs.rsc.org
Cyclin-dependent kinase 12 (CDK12) is a transcription-associated CDK that plays key roles
in transcription, translation, mRNA splicing, the cell cycle, and DNA damage repair …
in transcription, translation, mRNA splicing, the cell cycle, and DNA damage repair …