Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …

Recent technological advances have enabled DNA methylation to be assayed at single-cell
resolution. However, current protocols are limited by incomplete CpG coverage and hence …

Among the diverse transcription factors that are necessary to elicit changes in cell fate, both
in embryonic development and in cellular reprogramming, a subset of factors are capable of …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

All mammalian uteri contain glands in the endometrium that develop only or primarily after
birth. Gland development or adenogenesis in the postnatal uterus is intrinsically regulated …

Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

The specification of the vertebrate liver is thought to occur in a two-step process, beginning
with the establishment of competence within the foregut endoderm for responding to organ …

In the mammalian liver, bile is transported to the intestine through an intricate network of bile
ducts. Notch signaling is required for normal duct formation, but its mode of action has been …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …