A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated
movement, is widely accepted. Recent work has suggested that alterations in activity …

Dystonia is a neurological disorder characterized by involuntary twisting movements and
postures. There are many different clinical manifestations, and many different causes. The …

The circuit changes that mediate parkinsonian tremor, while likely differing from those
underlying akinesia and rigidity, are not precisely known. In this study, to identify a specific …

Dystonia is a movement disorder of both genetic and non-genetic causes, which typically
results in twisted posturing due to abnormal muscle contraction. Evidence from dystonia …

The dystonias are a heterogeneous group of hyperkinetic movement disorders
characterised by involuntary sustained muscle contractions that lead to abnormal postures …

Primary dystonia has traditionally been viewed as a basal ganglia disorder, but recent
studies suggest that the cerebellum plays a crucial role in the disease. Primary dystonia is …

DYT1 is a debilitating movement disorder caused by loss-of-function mutations in torsinA.
How these mutations cause dystonia remains unknown. Mouse models which have …

The neurobiological basis of psychogenic movement disorders remains poorly understood
and the management of these conditions difficult. Functional neuroimaging studies have …

Projections from thalamic intralaminar nuclei convey sensory signals to striatal cholinergic
interneurons. These neurons respond with a pause in their pacemaking activity, enabling …

The factors that determine symptom penetrance in inherited disease are poorly understood.
Increasingly, magnetic resonance diffusion tensor imaging (DTI) and PET are used to …