Basophils are the rarest granulocytes and represent less than 1% of peripheral blood
leukocytes. They are evolutionarily conserved in many animal species, but their functional …

The molecular apparatus that protects us against infection can also injure us by causing
autoimmune or autoinflammatory disease. It now seems that at times, defects within the …

Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express
together with IgM through alternative RNA splicing. Here we report active T cell–dependent …

Context.—Amyloidoses are disorders of diverse etiology in which deposits of abnormally
folded proteins share distinctive staining properties and fibrillar ultrastructural appearance …

The nucleotide-binding domain, leucine-rich repeat (NLR) proteins are a recently
discovered family of intracellular pathogen and danger signal sensors. NLRs have emerged …

Historically, pediatric inflammatory diseases were viewed as autoimmune but developments
in genetics of monogenic disease have supported our proposal that “inflammation against …

Caspase-1 is activated by the inflammasome complex to process cytokines like interleukin-
1β (IL-1β). Pro-caspase-1 consists of three domains, CARD, p20, and p10. Association of …

PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to
their substrates. Mutations in PSTPIP1 cause PAPA syndrome (P yogenic sterile A rthritis, P …

The binary classification of mammalian caspases as either apoptotic or inflammatory is now
obsolete. Emerging data indicate that all mammalian caspases are intricately involved in the …

Porcine reproductive and respiratory syndrome (PRRS) has devastated pig industries
worldwide for many years. It is caused by a small RNA virus (PRRSV), which targets almost …