Role of pharmacological active phthalazine scaffolds in medicinal chemistry
SMN Sakib - Open Science Foundation, 2023 - osf.io
Phthalazine derivatives have recently received a lot of interest in the realm of physiologically
active chemical research. Introduce this phthalazine moiety to a researcher in a new …
active chemical research. Introduce this phthalazine moiety to a researcher in a new …
Multicomponent chemistry in the synthesis of carbonic anhydrase inhibitors
Carbonic anhydrase inhibitors (CAIs) are of growing interest since various isoforms of the
enzyme are identified as promising drug targets for treatment of disease. The principal …
enzyme are identified as promising drug targets for treatment of disease. The principal …
One-pot procedure for the synthesis of asymmetric substituted ureido benzene sulfonamides as effective inhibitors of carbonic anhydrase enzymes
We report a one-pot procedure for the synthesis of asymmetrical ureido-containing
benzenesulfonamides based on in situ generation of the corresponding …
benzenesulfonamides based on in situ generation of the corresponding …
β-Cyclodextrin as a supramolecular catalyst for the synthesis of 2H-indazolo [2, 1-b] phthalazine-trione derivatives in water and their antimicrobial activities
AV Chate, PK Bhadke, MA Khande… - Chinese Chemical …, 2017 - Elsevier
An efficient and green method has been developed for the synthesis of 2H-indazolo [2, 1-b]
phthalazine-triones derivatives by employing 15 mol% β-cyclodextrinvia a one-pot …
phthalazine-triones derivatives by employing 15 mol% β-cyclodextrinvia a one-pot …
[HTML][HTML] Exploring heterocyclic scaffolds in carbonic anhydrase inhibition: a decade of structural and therapeutic insights
N Naeem, A Sadiq, GA Othman, HM Yassin… - RSC Advances, 2024 - pubs.rsc.org
Heterocyclic compounds represent a prominent class of molecules with diverse
pharmacological activities. Among their therapeutic applications, they have gained …
pharmacological activities. Among their therapeutic applications, they have gained …
Synthesis and characterization of Fe3O4@SiO2-(CH2)3-NH-Asn-M(II) (Cu (II)/ Ni(II)/ Co(II)) and its catalytic application in the synthesis of chromeno-pyrazolo …
SZ Mostashari, A Fallah Shojaei… - Research on Chemical …, 2022 - Springer
Abstract Fe 3 O 4@ SiO 2-(CH 2) 3-NH-Asn-Cu (II) was synthesized via functionalization of
synthesized Fe 3 O 4 with 3-aminopropyltriethoxysilane, asparagine, and Cu (OAc) 2. The …
synthesized Fe 3 O 4 with 3-aminopropyltriethoxysilane, asparagine, and Cu (OAc) 2. The …
Synthesis, biological activity and structure‐activity relationship of novel diphenylurea derivatives containing tetrahydroquinoline as carbonic anhydrase I and II …
A series of novel tetrahydroquinoline derivatives containing urea moiety was synthesized
and their in vitro inhibitory effects on the human carbonic anhydrase isoenzymes (hCA− I …
and their in vitro inhibitory effects on the human carbonic anhydrase isoenzymes (hCA− I …
Synthesis, characterization, carbonic anhydrase inhibitor activity, and docking studies of phenylthiazol-2 (3h)-ylidene-isoquinoline-5-amine Derivatives
Abstract Phenylthiazol-2 (3h)-ylidene-isoquinoline-5-amine derivatives (5a-r) were easily
prepared from 5-aminoisoquinoline, thioisocyanate, and phenacyl bromide derivatives in the …
prepared from 5-aminoisoquinoline, thioisocyanate, and phenacyl bromide derivatives in the …
[HTML][HTML] Phthalazine-triones: Calix [4] arene-assisted synthesis using green solvents and their anticancer activities against human cancer cells
YF Rego, CM da Silva, DL da Silva, JG da Silva… - Arabian journal of …, 2019 - Elsevier
Fourteen phthalazine-triones bearing different substituents at C-4 position were synthesized
through multicomponent reactions (MCR) by using phthalhydrazide, dimedone and diferent …
through multicomponent reactions (MCR) by using phthalhydrazide, dimedone and diferent …
[PDF][PDF] Role of pharmacological active phthalazine scaffolds in medicinal chemistry: A Mini-Review
The application of nitrogen-containing heterocyclic molecules in many fields, such as
pharmaceuticals, has gotten a lot of interest. Phthalazine and its oxygenated derivatives …
pharmaceuticals, has gotten a lot of interest. Phthalazine and its oxygenated derivatives …