Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Breast cancer is the most common cancer and leading cause of cancer death among
women worldwide, encompassing a wide heterogeneity of subtypes with different clinical …

Type 1 diabetes mellitus (T1DM) is a disease where destruction of the insulin producing
pancreatic beta-cells leads to increased blood sugar levels. Both genetic and environmental …

Angiogenesis is a fundamental process that involves in tumor progression and metastasis.
Vascular endothelial growth factor (VEGF) family and their receptors are identified as the …

It is well recognized that most cancers derive and progress from transformation and clonal
expansion of a single cell that possesses stem cell properties, ie, self-renewal and …

Background Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box
domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell …

In order to enhance the penetration of small interference RNA against the polo-like kinase I
(siPLK1) across BBB to treat glioblastoma (GBM), transferrin (Tf) modified magnetic …

Zinc-finger proteins (ZFPs) are the largest transcription factor family in mammals, involved in
the regulation of multiple physiologic processes including cell differentiation, proliferation …

Cancer is recognized as a preeminent factor of the world's mortality. Although various
modalities have been designed to cure this life-threatening ailment, a significant impediment …

Abstract Approximately 15-20% of breast carcinomas exhibit human epidermal growth factor
receptor (HER2) protein overexpression. HER2-positive breast cancer (BC) is a …