Improving the Supply and Quality of Deceased-Donor Organs for Transplantation | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Background Significant numbers of patients in the USA and UK die while waiting for solid
organ transplant. Only 1–2% of deaths are eligible as donors with a fraction of the deceased …

Importance Ischemic cold storage (ICS) of livers for transplant is associated with serious
posttransplant complications and underuse of liver allografts. Objective To determine …

Older organs represent an untapped potential to close the gap between demand and supply
in organ transplantation but are associated with age-specific responses to injury and …

The availability of direct-acting antiviral agents for the treatment of hepatitis C virus (HCV)
infection has resulted in a profound shift in the approach to the management of this infection …

Background The proportion of deceased donor kidneys recovered for transplant but
discarded increased steadily in the United States over 2 decades, from 5.1% in 1988 to …

Objective: Normothermic machine perfusion (NMP) enables optimized ex-vivo preservation
of a donor liver in a normal physiologic state. The impact of this emerging technology on …

Liver cryopreservation has the potential to enable indefinite organ banking. This study
investigated vitrification—the ice-free cryopreservation of livers in a glass-like state—as a …

In our studies of life-supporting α-1, 3-galactocyltransferase knockout (GalT-KO) pig-to-
baboon kidneys, we found that some recipients developed increased serum creatinine with …

Despite improvements in postliver transplant outcomes through refinements in perioperative
management and surgical techniques, several changing trends in liver transplantation have …