Essential tremor pathology: neurodegeneration and reorganization of neuronal connections

ED Louis, PL Faust - Nature Reviews Neurology, 2020 - nature.com
Essential tremor (ET) is the most common tremor disorder globally and is characterized by
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …

The cerebral basis of Parkinsonian tremor: a network perspective

RC Helmich - Movement Disorders, 2018 - Wiley Online Library
Tremor in Parkinson's disease is a poorly understood sign. Although it is one of the clinical
hallmarks of the disease, its pathophysiology remains unclear. It is clear that tremor involves …

Expansion of GGC repeat in the human-specific NOTCH2NLC gene is associated with essential tremor

QY Sun, Q Xu, Y Tian, ZM Hu, LX Qin, JX Yang… - Brain, 2020 - academic.oup.com
Essential tremor is one of the most common movement disorders. Despite its high
prevalence and heritability, the genetic aetiology of essential tremor remains elusive. Up to …

Essential tremor: the most common form of cerebellar degeneration?

ED Louis, PL Faust - Cerebellum & ataxias, 2020 - Springer
Background The degenerative cerebellar ataxias comprise a large and heterogeneous
group of neurological diseases whose hallmark clinical feature is ataxia, and which are …

[HTML][HTML] Prospective home-use study on non-invasive neuromodulation therapy for essential tremor

SH Isaacson, E Peckham, W Tse, O Waln… - Tremor and Other …, 2020 - ncbi.nlm.nih.gov
Background: Two previous randomized, controlled, single-session trials demonstrated
efficacy of non-invasive neuromodulation therapy targeting the median and radial nerves for …

[HTML][HTML] The olivary hypothesis of essential tremor: time to lay this model to rest?

ED Louis, A Lenka - Tremor and other hyperkinetic movements, 2017 - ncbi.nlm.nih.gov
Background Although essential tremor (ET) is the most common tremor disorder, its
pathogenesis is not fully understood. The traditional model of ET, proposed in the early …

Is essential tremor a single entity?

F Hopfner, G Deuschl - European journal of neurology, 2018 - Wiley Online Library
Essential tremor (ET) is a frequent movement disorder. The new tremor classification has
subdivided ET into the classical form with bilateral action tremor of the hands with or without …

The etiology of essential tremor: Genes versus environment

F Hopfner, RC Helmich - Parkinsonism & related disorders, 2018 - Elsevier
Introduction Essential tremor (ET) is characterized by bilateral upper limb action tremor.
Here we review the pathophysiology (cerebral mechanisms) and etiology (genetic and …

Non-invasive electrical stimulation of peripheral nerves for the management of tremor

A Pascual-Valdunciel, A Rajagopal, JL Pons… - Journal of the …, 2022 - Elsevier
Pathological tremor in patients with essential tremor and Parkinsons disease is typically
treated using medication or neurosurgical interventions. There is a widely recognized need …

[HTML][HTML] Cerebellar α6GABAA receptors as a therapeutic target for essential tremor: proof-of-concept study with ethanol and pyrazoloquinolinones

YH Huang, MT Lee, HY Hsueh, DE Knutson, J Cook… - …, 2023 - Elsevier
Ethanol has been shown to suppress essential tremor (ET) in patients at low-to-moderate
doses, but its mechanism (s) of action remain unknown. One of the ET hypotheses attributes …