Dendritic spines are small protrusive structures on dendritic surfaces, and function as
postsynaptic compartments for excitatory synapses. Plasticity of spine structure is associated …

Blast-induced traumatic brain injury (TBI) has become a signature wound of recent military
activities and is the leading cause of death and long-term disability among US soldiers. The …

Dendritic spines are mushroom-shaped postsynaptic compartments that host biochemical
signal cascades important for synaptic plasticity and, ultimately, learning and memory …

Objective: Like all scientific research, computational neuroscience research must be
reproducible. Big data science, including simulation research, cannot depend exclusively on …

Detailed conductance-based nonlinear neuron models consisting of thousands of synapses
are key for understanding of the computational properties of single neurons and large …

In order to support research on the role of cell biological principles (genomics, proteomics,
signaling cascades and reaction dynamics) on the dynamics of neuronal response in health …

Signaling pathways are cascades of intracellular biochemical reactions that are activated by
transmembrane receptors, and ultimately lead to transcription in the nucleus. In neurons …

Neurons exhibit remarkably complex geometry in their neurite networks. So far, how
materials are transported in the complex geometry for survival and function of neurons …

Biological signalling systems are complex, and efforts to build mechanistic models must
confront a huge parameter space, indirect and sparse data, and frequently encounter …

The subject of the effects of the active properties of the Purkinje cell dendrite on neuronal
function has been an active subject of study for more than 40 years. Somewhat unusually …