Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

Proper regulation and management of energy, substrate diversity and quantity, as well as
macromolecular synthesis and breakdown processes, are fundamental to cellular and …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

In addition to their bioenergetic intracellular function, several classical metabolites act as
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …

Highly ordered interactions between immune and metabolic responses are evolutionarily
conserved and paramount for tissue and organismal health. Disruption of these interactions …

Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell
function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta …

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite
for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

One explanation for the increased incidence of allergies, asthma, and even some
autoimmune diseases has been the hygiene hypothesis. However, recent studies also …