Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
Depression in neurodegenerative diseases: Common mechanisms and current treatment options
CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …
cause of disability worldwide. This neurological condition is commonly associated with …
The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression
P Czarny, P Wigner, P Galecki, T Sliwinski - Progress in Neuro …, 2018 - Elsevier
A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …
oxidant-antioxidant imbalance may play a significant role in the development and …
Burrowing and nest building behavior as indicators of well-being in mice
P Jirkof - Journal of neuroscience methods, 2014 - Elsevier
The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-
reduction strategies, is crucial in animal experimentation but can be challenging in …
reduction strategies, is crucial in animal experimentation but can be challenging in …
Conditional BDNF delivery from astrocytes rescues memory deficits, spine density, and synaptic properties in the 5xFAD mouse model of Alzheimer disease
B de Pins, C Cifuentes-Díaz, AT Farah… - Journal of …, 2019 - Soc Neuroscience
It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …
Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice
The mechanisms underlying Tau-related synaptic and cognitive deficits and the
interrelationships between Tau species, their clearance pathways, and synaptic impairments …
interrelationships between Tau species, their clearance pathways, and synaptic impairments …
Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model
S Arora, T Kanekiyo, J Singh - International Journal of Biological …, 2022 - Elsevier
Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …
Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory.
Recently, US Food and Drug Administration mitigated the standard for drug approval …
Recently, US Food and Drug Administration mitigated the standard for drug approval …
Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer's amyloid-β oligomers in mice
Considerable clinical and epidemiological evidence links Alzheimer's disease (AD) and
depression. However, the molecular mechanisms underlying this connection are largely …
depression. However, the molecular mechanisms underlying this connection are largely …
Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)
3xTg-AD mutant mice are characterized by parenchymal Aβ plaques and neurofibrillary
tangles resembling those found in patients with Alzheimer's disease. The mutants were …
tangles resembling those found in patients with Alzheimer's disease. The mutants were …