In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

The biophysical features of neurons shape information processing in the brain. Cortical
neurons are larger in humans than in other species, but it is unclear how their size affects …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Understanding cortical circuits will require mapping the connections between specific
populations of neurons, as well as determining the dendritic locations where the synapses …

In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5)
extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these …

One of the central questions in neuroscience is how particular tasks, or computations, are
implemented by neural networks to generate behavior. The prevailing view has been that …

Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5
pyramidal neurons, but their properties remain obscure. We report the existence of N-methyl …