Background Despite initial reports of a decline in use in the early 2000s, methamphetamine
remains a significant public health concern with known neurotoxic and neurocognitive …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Methamphetamine dependence is a serious worldwide public health problem with major
medical, psychiatric, socioeconomic and legal consequences. Various neuronal …

Drug self-administration models of addiction typically require animals to make the same
response (eg, a lever-press or nose-poke) over and over to procure and take drugs. By their …

Objective: Currently there is no approved pharmacotherapy for amphetamine dependence.
Recent human laboratory studies have demonstrated that naltrexone modulates some of the …

Introduction: Methamphetamine use is a serious public health concern in many countries
and is second to cannabis as the most widely abused illicit drug in the world. Effective …

Rationale Methamphetamine is a highly addictive psychostimulant, and chronic
methamphetamine users show high rates of relapse. Furthermore, prolonged …

Background Methamphetamine abuse has become an increasing problem in both the
United States and globally with concomitant increases in adverse medical, social and …

Glutamate signaling plays an essential role in drug-seeking behavior. Using reinstatement
of conditioned place preference (CPP), we determined whether ceftriaxone, a β-lactam …

Methamphetamine (MA) use disorder is a serious psychiatric condition for which there are
no FDA-approved medications. Naltrexone (NTX) is an opioid receptor antagonist with …