Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …

Extracellular matrix (ECM) plays a central and dynamic role in the creation of tumor
microenvironment. Herein we discuss the emerging biophysical and biochemical aspects of …

Heparan sulfates are complex polysaccharides that mediate the interaction with a broad
range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is …

Previous studies have found that the novel low-elastic-modulus Ti2448 alloy can
significantly reduce stress shielding and contribute to better bone repair than the …

The endothelial glycocalyx is a negatively charged, carbohydrate-rich structure that arises
from the luminal surface of the vascular endothelium and is comprised of proteoglycans …

Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …

Background Oral health is of fundamental importance to maintain systemic health in
humans. Stem cell-based oral tissue regeneration is a promising strategy to achieve the …

In this comprehensive review, we will dissect the impact of research on proteoglycans
focusing on recent developments involved in their synthesis, degradation, and interactions …

Decorin is a stromal-derived prototype member of the small leucine-rich proteoglycan gene
family. In addition to its functions as a regulator of collagen fibrillogenesis and TGF-β activity …

Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria
in many systemic and localized vascular disorders. Among them are the thrombotic …