The neonatal Fc receptor (FcRn): a misnomer?

M Pyzik, KMK Sand, JJ Hubbard, JT Andersen… - Frontiers in …, 2019 - frontiersin.org
Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

Cadmium handling, toxicity and molecular targets involved during pregnancy: lessons from experimental models

T Jacobo-Estrada, M Santoyo-Sánchez… - International journal of …, 2017 - mdpi.com
Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is
still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific …

A critical review on the opportunity to use placenta and innovative biomonitoring methods to characterize the prenatal chemical exposome

T Contini, R Béranger, L Multigner… - Environmental …, 2023 - ACS Publications
Adverse effects associated with chemical exposures during pregnancy include several
developmental and reproductive disorders. However, considering the tens of thousands of …

Cadmium exposure and risk of adverse pregnancy and birth outcomes: a systematic review and dose–response meta-analysis of cohort and cohort-based case …

AK Amegah, C Sewor, JJK Jaakkola - Journal of Exposure Science & …, 2021 - nature.com
Background There are several inconsistencies in the epidemiological literature on the
strength of the association between cadmium exposure and adverse pregnancy and birth …

Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease

JR Charlton, W Tan, G Daouk, L Teot… - American Journal …, 2020 - journals.physiology.org
Pathogenic variants in the LRP2 gene, encoding the multiligand receptor megalin, cause a
rare autosomal recessive syndrome: Donnai-Barrow/Facio-Oculo-Acoustico-Renal …

Megalin, proton pump inhibitors and the renin–angiotensin system in healthy and pre-eclamptic placentas

Y Sun, L Tan, RI Neuman, M Broekhuizen… - International Journal of …, 2021 - mdpi.com
Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump
inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To investigate whether PPIs …

FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of …

J Zikos, GM Webb, HL Wu, JS Reed, J Watanabe… - Mabs, 2024 - Taylor & Francis
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be
exploited to prevent viral infections during pregnancy and early life. To reach protective …

[HTML][HTML] Trace elements and APOE polymorphisms in pregnant women and their new-borns

A Trdin, JS Tratnik, A Stajnko, J Marc, D Mazej… - Environment …, 2020 - Elsevier
We investigated the relationship between lipid binding glycoprotein apolipoprotein E (apoE;
gene APOE) polymorphisms (ε4 allele carriers versus no carriers= ε4+/ε4−) and trace …

The Distinct Role of the HDL Receptor SR-BI in Cholesterol Homeostasis of Human Placental Arterial and Venous Endothelial Cells

M Strahlhofer-Augsten, C Schliefsteiner… - International Journal of …, 2022 - mdpi.com
As opposed to adults, high-density lipoprotein (HDL) is the main cholesterol carrying
lipoprotein in fetal circulation. The major HDL receptor, scavenger receptor class B type I …

Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types

MQ Rasmussen, G Tindbæk, MM Nielsen, C Merrild… - Cancers, 2023 - mdpi.com
Simple Summary Epithelial tissues are the most common sites for the development of
cancer. Loss of epithelial cell characteristics and dedifferentiation are hallmarks of cancer. A …