Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Intracellular iron levels are strictly regulated to support homeostasis and avoid iron-
mediated ROS production. Loss of iron-sulfur cluster (ISC) synthesis can increase iron …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Abstract Iron–sulfur (Fe–S) clusters are versatile protein cofactors that require numerous
components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of …

Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis,
transfer, and insertion into target proteins require many components. Mitochondrial ISC …

Iron-sulfur (Fe-S) clusters are ubiquitous cofactors composed of iron and inorganic sulfur.
They are required for the function of proteins involved in a wide range of activities, including …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …

Ferroptosis is characterized as a novel form of regulated cell death, which is initiated by the
lethal accumulation of lipid peroxidation catalyzed by cellular labile free iron. This iron …