Accessibility and conservation: general features of bacterial small RNA–mRNA interactions?

A Richter, R Backofen - RNA biology, 2012 - Taylor & Francis
Bacterial small RNAs (sRNAs) are a class of structural RNAs that often regulate mRNA
targets via post-transcriptional base pair interactions. We determined features that …

Fast accessibility-based prediction of RNA–RNA interactions

H Tafer, F Amman, F Eggenhofer, PF Stadler… - …, 2011 - academic.oup.com
Motivation: Currently, the best RNA–RNA interaction prediction tools are based on
approaches that consider both the inter-and intramolecular interactions of hybridizing RNAs …

PETcofold: predicting conserved interactions and structures of two multiple alignments of RNA sequences

SE Seemann, AS Richter, T Gesell, R Backofen… - …, 2011 - academic.oup.com
Abstract Motivation: Predicting RNA–RNA interactions is essential for determining the
function of putative non-coding RNAs. Existing methods for the prediction of interactions are …

Bioinformatics of prokaryotic RNAs

R Backofen, F Amman, F Costa, S Findeiß… - RNA biology, 2014 - Taylor & Francis
The genome of most prokaryotes gives rise to surprisingly complex transcriptomes,
comprising not only protein-coding mRNAs, often organized as operons, but also harbors …

The PETfold and PETcofold web servers for intra-and intermolecular structures of multiple RNA sequences

SE Seemann, P Menzel, R Backofen… - Nucleic acids …, 2011 - academic.oup.com
The function of non-coding RNA genes largely depends on their secondary structure and the
interaction with other molecules. Thus, an accurate prediction of secondary structure and …

RNA–RNA interaction prediction based on multiple sequence alignments

AX Li, M Marz, J Qin, CM Reidys - Bioinformatics, 2011 - academic.oup.com
Motivation: Many computerized methods for RNA–RNA interaction structure prediction have
been developed. Recently, O (N 6) time and O (N 4) space dynamic programming …

IRBIS: a systematic search for conserved complementarity

DD Pervouchine - RNA, 2014 - rnajournal.cshlp.org
IRBIS is a computational pipeline for detecting conserved complementary regions in
unaligned orthologous sequences. Unlike other methods, it follows the “first-fold-then-align” …

Comparative RNA genomics

R Backofen, J Gorodkin, IL Hofacker… - … Genomics: Methods and …, 2018 - Springer
Over the last two decades it has become clear that RNA is much more than just a boring
intermediate in protein expression. Ancient RNAs still appear in the core information …

Computational prediction of RNA–RNA interactions

R Backofen - … Sequence, Structure, and Function: Computational and …, 2014 - Springer
We describe different tools and approaches for RNA–RNA interaction prediction.
Recognition of ncRNA targets is predominantly governed by two principles, namely the …

Using binding profiles to predict binding sites of target RNAs

U Poolsap, Y Kato, K Sato, T Akutsu - Journal of Bioinformatics and …, 2011 - World Scientific
Prediction of RNA–RNA interaction is a key to elucidating possible functions of small non-
coding RNAs, and a number of computational methods have been proposed to analyze …