Facilitation of sensory transmission to motoneurons during cortical or sensory‐evoked primary afferent depolarization (PAD) in humans

K Metz, IC Matos, Y Li, B Afsharipour… - The Journal of …, 2023 - Wiley Online Library
Sensory and corticospinal tract (CST) pathways activate spinal GABAergic interneurons that
have axoaxonic connections onto proprioceptive (Ia) afferents that cause long‐lasting …

Presynaptic inhibition selectively suppresses leg proprioception in behaving Drosophila

CJ Dallmann, Y Luo, S Agrawal, GM Chou, A Cook… - …, 2024 - pmc.ncbi.nlm.nih.gov
Controlling arms and legs requires feedback from proprioceptive sensory neurons that
detect joint position and movement. Proprioceptive feedback must be tuned for different …

Post‐activation depression from primary afferent depolarization (PAD) produces extensor H‐reflex suppression following flexor afferent conditioning

K Metz, IC Matos, K Hari, O Bseis… - The Journal of …, 2023 - Wiley Online Library
Suppression of the extensor H‐reflex by flexor afferent conditioning is thought to be
produced by a long‐lasting inhibition of extensor Ia afferent terminals via GABAA receptor …

Modulation of sensory input to the spinal cord: Contribution of focal epidural polarization and of GABA released by interneurons and glial cells

I Hammar, E Jankowska - European Journal of Neuroscience, 2024 - Wiley Online Library
Modulation of input from primary afferent fibres has long been examined at the level of the
first relays of these fibres. However, recent studies reveal that input to the spinal cord may …

Tapping into the human spinal locomotor centres with transspinal stimulation

A Skiadopoulos, M Knikou - Scientific Reports, 2024 - nature.com
Human locomotion is controlled by spinal neuronal networks of similar properties, function,
and organization to those described in animals. Transspinal stimulation affects the spinal …

Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice

H Zhang, D Deska-Gauthier, CS MacKay, K Hari… - Cell Reports, 2025 - cell.com
While considerable progress has been made in understanding the neuronal circuits that
underlie the patterning of locomotor behaviors, less is known about the circuits that amplify …

Medial and lateral vestibulospinal projections to the cervical spinal cord of the squirrel monkey

R Boyle - Frontiers in Neurology, 2025 - frontiersin.org
Introduction The brainstem vestibular nuclei neurons receive synaptic inputs from inner ear
acceleration-sensing hair cells, cerebellar output neurons, and ascending signals from …

Skin and not dorsal root stimulation reduces hypertonus in thoracic motor complete spinal cord injury: a single case report

B Lieu, DG Everaert, C Ho… - Journal of …, 2024 - journals.physiology.org
On demand and localized treatment for excessive muscle tone after spinal cord injury (SCI)
is currently not available. Here, we examine the reduction in leg hypertonus in a person with …

Modulation of input to the spinal cord; contribution of GABA released by interneurons and glial cells by polarization at the entry of sensory information

E Jankowska, I Hammar - bioRxiv, 2024 - biorxiv.org
Modulation of input from primary afferent fibres has long been examined at the level of the
first relay neurons of these fibres. However, recent studies reveal that input to the spinal cord …

Modulation of sensory input to the spinal cord by peripheral afferent fibres. Searching for relays

U Slawinska, I Hammar, E Jankowska - bioRxiv, 2024 - biorxiv.org
A long-lasting GABA-dependent increase in the excitability of afferent fibres, and thus
modulation of the sensory input to the spinal cord, may be evoked by epidural polarization …