While the development of positron emission tomography (PET) radiopharmaceuticals
closely follows that of traditional drug development, there are several key considerations in …

Introduction There are several new and emerging antipsychotic medication strategies
recently marketed or under clinical development for the treatment of several mental …

Chemical probes are critical tools for elucidating the biological functions of proteins and can
lead to new medicines for treating disease. The pharmacological validation of protein …

Somnolence is a common side effect of antipsychotics. To assess the incidence of this side
effect, we performed a MEDLINE search for randomized, double-blinded, placebo-or active …

The accurate and precise determination of binding interactions plays a central role in fields
such as drug discovery where structure–activity relationships guide the selection and …

Agonists of benzodiazepine (BZD) binding site in GABA receptors are widely used in clinical
practice. In spite of their benefits they have several side effects, so synthesis of new agonists …

Abstract Background Fragile X syndrome (FXS) is a common inherited form of intellectual
disability caused by loss of function of the fragile X mental retardation protein. Recent animal …

Cannabinoid, free fatty acid, lysophosphatidic acid, sphingosine 1-phosphate, prostanoid,
leukotriene, bile acid, and platelet-activating factor receptor families are class AG protein …

Introduction Aspects of radiopharmaceutical development are illustrated through preclinical
studies of [125 I]-(E)-1-(2-(2, 3-dihydrobenzofuran-5-yl) ethyl)-4-(iodoallyl) piperazine ([125 I] …

Prostate carcinoma is the most common non-cutaneous malignancy in males. Imaging of
prostatic lesions is of great importance and aids in oncologic management and monitoring of …