Mitochondria targeting as an effective strategy for cancer therapy
Mitochondria are well known for their role in ATP production and biosynthesis of
macromolecules. Importantly, increasing experimental evidence points to the roles of …
macromolecules. Importantly, increasing experimental evidence points to the roles of …
PGRMC1: an enigmatic heme-binding protein
MR McGuire, PJ Espenshade - Pharmacology & therapeutics, 2023 - Elsevier
Abstract Progesterone Receptor Membrane Component 1 (PGRMC1) is a heme-binding
protein that has been implicated in a wide range of cell and tissue functions, including …
protein that has been implicated in a wide range of cell and tissue functions, including …
Ibuprofen induces an allosteric conformational transition in the heme complex of human serum albumin with significant effects on heme ligation
FP Nicoletti, BD Howes, M Fittipaldi… - Journal of the …, 2008 - ACS Publications
Human serum albumin (HSA), the most prominent protein in blood plasma, is able to bind a
wide range of endogenous and exogenous compounds. Among the endogenous ligands …
wide range of endogenous and exogenous compounds. Among the endogenous ligands …
Characterization of Heme Ligation Properties of Rv0203, a Secreted Heme Binding Protein Involved in Mycobacterium tuberculosis Heme Uptake
The secreted Mycobacterium tuberculosis (Mtb) heme binding protein Rv0203 has been
shown to play a role in Mtb heme uptake. In this work, we use spectroscopic (absorption …
shown to play a role in Mtb heme uptake. In this work, we use spectroscopic (absorption …
Structure-based mechanism for oxidative decarboxylation reactions mediated by amino acids and heme propionates in coproheme decarboxylase (HemQ)
Coproheme decarboxylase catalyzes two sequential oxidative decarboxylations with H2O2
as the oxidant, coproheme III as substrate and cofactor, and heme b as the product. Each …
as the oxidant, coproheme III as substrate and cofactor, and heme b as the product. Each …
Spectroscopic and mutagenesis studies of human PGRMC1
Progesterone receptor membrane component 1 (PGRMC1) is a 25 kDa protein with an N-
terminal transmembrane domain and a putative C-terminal cytochrome b5 domain. Heme …
terminal transmembrane domain and a putative C-terminal cytochrome b5 domain. Heme …
Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme that also
functions in transcriptional regulation, oxidative stress, vesicular trafficking, and apoptosis …
functions in transcriptional regulation, oxidative stress, vesicular trafficking, and apoptosis …
What can be learned from nuclear resonance vibrational spectroscopy: Vibrational dynamics and hemes
WR Scheidt, J Li, JT Sage - Chemical reviews, 2017 - ACS Publications
Nuclear resonance vibrational spectroscopy (NRVS; also known as nuclear inelastic
scattering, NIS) is a synchrotron-based method that reveals the full spectrum of vibrational …
scattering, NIS) is a synchrotron-based method that reveals the full spectrum of vibrational …
Recent advances in bacterial heme protein biochemistry
JA Mayfield, CA Dehner, JL DuBois - Current opinion in chemical biology, 2011 - Elsevier
Recent progress in genetics, fed by the burst in genome sequence data, has led to the
identification of a host of novel bacterial heme proteins that are now being characterized in …
identification of a host of novel bacterial heme proteins that are now being characterized in …
Kinetic and Spectroscopic Studies of Hemin Acquisition in the Hemophore HasAp from Pseudomonas aeruginosa
ET Yukl, G Jepkorir, AY Alontaga, L Pautsch… - Biochemistry, 2010 - ACS Publications
The extreme limitation of free iron has driven various pathogens to acquire iron from the host
in the form of heme. Specifically, several Gram-negative pathogens secrete a heme binding …
in the form of heme. Specifically, several Gram-negative pathogens secrete a heme binding …