Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy
Cognitive and behavioural comorbidities are prevalent in childhood and adult epilepsies
and impose a substantial human and economic burden. Over the past century, the classic …
and impose a substantial human and economic burden. Over the past century, the classic …
Temporal lobe epilepsy and psychiatric comorbidity
V Vinti, GB Dell'Isola, G Tascini, E Mencaroni… - Frontiers in …, 2021 - frontiersin.org
Most focal seizures originate in the temporal lobe and are commonly divided into mesial and
lateral temporal epilepsy, depending upon the neuronal circuitry involved. The hallmark …
lateral temporal epilepsy, depending upon the neuronal circuitry involved. The hallmark …
Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …
but associations between neurobiological mechanisms and macroscale connectomics …
Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study
Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-
analysis, we integrated neuroimaging and connectome analysis to identify network …
analysis, we integrated neuroimaging and connectome analysis to identify network …
Temporal lobe epilepsy surgical outcomes can be inferred based on structural connectome hubs: a machine learning study
E Gleichgerrcht, SS Keller, DL Drane… - Annals of …, 2020 - Wiley Online Library
Objective Medial temporal lobe epilepsy (TLE) is the most common form of medication‐
resistant focal epilepsy in adults. Despite removal of medial temporal structures, more than …
resistant focal epilepsy in adults. Despite removal of medial temporal structures, more than …
Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference
Artificial intelligence (AI)-based tools are widely employed, but their use for diagnosis and
prognosis of neurological disorders is still evolving. Here we analyse a cross-sectional …
prognosis of neurological disorders is still evolving. Here we analyse a cross-sectional …
Decomposing MRI phenotypic heterogeneity in epilepsy: a step towards personalized classification
In drug-resistant temporal lobe epilepsy, precise predictions of drug response, surgical
outcome and cognitive dysfunction at an individual level remain challenging. A possible …
outcome and cognitive dysfunction at an individual level remain challenging. A possible …
Epilepsy in neurodegenerative diseases: related drugs and molecular pathways
A Cano, E Fonseca, M Ettcheto, E Sánchez-López… - Pharmaceuticals, 2021 - mdpi.com
Epilepsy is a chronic disease of the central nervous system characterized by an electrical
imbalance in neurons. It is the second most prevalent neurological disease, with 50 million …
imbalance in neurons. It is the second most prevalent neurological disease, with 50 million …
The ENIGMA‐Epilepsy working group: Mapping disease from large data sets
Epilepsy is a common and serious neurological disorder, with many different constituent
conditions characterized by their electro clinical, imaging, and genetic features. MRI has …
conditions characterized by their electro clinical, imaging, and genetic features. MRI has …
Functional connectome contractions in temporal lobe epilepsy: Microstructural underpinnings and predictors of surgical outcome
Objective Temporal lobe epilepsy (TLE) is the most common drug‐resistant epilepsy in
adults. Although it is commonly related to hippocampal pathology, increasing evidence …
adults. Although it is commonly related to hippocampal pathology, increasing evidence …