Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Prostate cancer is the second leading cause of death from cancer among males in Western
countries. It is also the most commonly diagnosed male cancer in Japan. The progression of …

Amplification of MYCN plays a pivotal role in multiple types of tumors and correlates with
poor prognosis in high-risk neuroblastoma. Despite recent advances in the treatment of …

This study was designed to purify molecules possess anti-cancer cell activity from the fruit
body of Ganoderma leucocontextum. Bio-activity-guided purification and chromatographic …

PIK3CA is the most frequently mutated oncogene in cervical cancer, and somatic mutations
in the PIK3CA gene result in increased activity of PI3K. In cervical cancer, the E545K …

Transcription therapy is an emerging approach that centers on identifying the factors
associated with the malfunctioning gene transcription machinery that causes diseases and …

Angiogenic factors have been demonstrated to play important roles in modulating
angiogenesis of solid tumors. Recently, accumulating studies extensively indicated that …

Gastric cancer (GC) is a leading cause of cancer‐related deaths worldwide. The Tff1
knockout (KO) mouse model develops gastric lesions that include low‐grade dysplasia …

As the energy factory for the cell, the mitochondrion, through its role of adenosine
triphosphate production by oxidative phosphorylation, can be regarded as the guardian of …

Pyrrole-imidazole polyamides are versatile DNA minor groove binders and attractive
therapeutic options against oncological targets, especially upon functionalization with an …