Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with
its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard …

An accumulating body of evidence suggests that endocannabinoids and cannabinoid
receptors type 1 and 2 (CB 1, CB 2) play a significant role in physiologic and pathologic …

To investigate the mechanisms involved in cannabidiol (CBD)-induced neuroprotection in
hypoxic–ischemic (HI) immature brain, forebrain slices from newborn mice underwent …

Endocannabinoids are released following brain injury and may protect against excitotoxic
damage during the acute stage of injury. Brain injury also activates microglia in a secondary …

Two types of cannabinoid receptor have been cloned and characterized. Whereas CB 1
receptors are ubiquitously expressed in neurons of the CNS, CB 2 receptors have been …

Microglial cells are recognized as the brain's intrinsic immune cells, mediating actions that
range from the protection against harmful conditions that modify CNS homeostasis, to the …

The presence of functional cannabinoid CB2 receptors in the CNS has provoked
considerable controversy over the past few years. Formerly considered as an exclusively …

Cannabinoids form a singular family of plant-derived compounds (phytocannabinoids),
endogenous signaling lipids (endocannabinoids), and synthetic derivatives with multiple …

Cannabinoid type 2 (CB2) agonists are neuroprotective and appear to play modulatory roles
in neurodegenerative processes in Alzheimer's disease. We have studied the effect of 1-((3 …

Purpose: Cannabinoids have been recently proposed as a new family of potential antitumor
agents. The present study was undertaken to investigate the expression of the two …