Motor thalamus (Mthal) is implicated in the control of movement because it is strategically
located between motor areas of the cerebral cortex and motor-related subcortical structures …

The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for
processing motor and non-motor information through the creation of complex connections …

Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia)
have a long history and primarily model the consequences of dopamine loss in the basal …

The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …

Deep brain stimulation (DBS) has been successfully applied in various neurodegenerative
diseases as an effective symptomatic treatment. However, its mechanisms of action within …

Deep brain stimulation (DBS) is an emerging interventional therapy for well-screened
patients with specific treatment-resistant neuropsychiatric diseases. Some neuropsychiatric …

The identification of distinct cell types in the basal ganglia has been critical to our
understanding of basal ganglia function and the treatment of neurological disorders. The …

The basal ganglia (BG)-recipient thalamus controls motor output but it remains unclear how
its activity is regulated. Several studies report that thalamic activation occurs via disinhibition …

Biophysical computational models are complementary to experiments and theories,
providing powerful tools for the study of neurological diseases. The focus of this review is the …

Movement disorders arise from the complex interplay of multiple changes to neural circuits.
Successful treatments for these disorders could interact with these complex changes in …